Structure of PDB 4m71 Chain B

Receptor sequence
>4m71B (length=332) Species: 1912 (Streptomyces hygroscopicus) [Search protein sequence]
SEAQARRAVADIFNSTLASSAIGAAWELGALDELRENGKLDVSDFAVRHD
LHEPAVVGMFTALASVGIVRREGATVVVGPYFDEANHHRSLFHWLNQGSG
ELFRRMPQVLPNENRTGKFYQLDAGAISYACREISERYFDPAFWAAVDGL
GYTPTTVADLGSGSGERLIQIARRFPGVRGLGVDIADGAIAMAEKEVAAK
GFGDQISFVRGDARTIDQVSARGEFAEVDLLTCFMMGHEFWPRENCVQTL
RKLRAAFPNVRRFLLGDATRTVGIPDRELPVFTLGFEFGHDMMGVYLPTL
DEWDGVFEEGGWRCVKKHAIDSLSVSVVFELE
3D structure
PDB4m71 Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.281: phenylpyruvate C(3)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G166 D189 I190 F239 M240 M241 G161 D184 I185 F234 M235 M236
BS02 56D B M240 H243 F287 F291 H295 M235 H238 F282 F286 H290
BS03 FE B H243 H295 H238 H290
BS04 HF2 B D309 C319 V320 K321 K322 D304 C314 V315 K316 K317
BS05 CA B P112 Q113 P107 Q108
BS06 CA B K44 D46 K39 D41
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4m71, PDBe:4m71, PDBj:4m71
PDBsum4m71
PubMed24914966
UniProtQ643C8|MPPJ_STRHY Phenylpyruvate C(3)-methyltransferase (Gene Name=mppJ)

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