Structure of PDB 4m1s Chain B

Receptor sequence
>4m1sB (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVSYRKQVVIDGETSLLDILDTA
GQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVKDSEDV
PMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTL
VREIRKHKE
3D structure
PDB4m1s K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
ChainB
Resolution1.552 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 21K B V9 G10 C12 R68 M72 Y96 V9 G10 C12 R59 M63 Y87
BS02 GDP B G13 G15 K16 S17 A18 F28 N116 K117 D119 S145 A146 G13 G15 K16 S17 A18 F28 N107 K108 D110 S136 A137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m1s, PDBe:4m1s, PDBj:4m1s
PDBsum4m1s
PubMed24256730
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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