Structure of PDB 4lwp Chain B

Receptor sequence
>4lwpB (length=342) [Search protein sequence]
SDLAVHRLMLEDAQRMSFYRKSIEQSASIEGKVVVDVGSGTGILSMWAAR
AGAKHVFSIEASSLSEFQIGVVEDNDLSTKITVLGDTVENIIAGGVANFV
NRHKAKLGKCGVAVLLSEWMGFYLFHEGMLPSVIRARNFFQDVNAALGVL
QPIEMIPERATVFVAPITCKPYYVQRYKNFWRDVDGLDFSRYGRIEYEVY
LEQPLVECLPPLCLLHEGLSLIELNLSTVQEEVLTSLHNTVHFDLKESAE
FQQHAREAGSEGRVSVDGFTVWFDVSYGAHTLSTSPRSPSTHWKQTTILL
PREARNEELVSFPVEGGELGVEMHISASDKTLRFYTIELELK
3D structure
PDB4lwp Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei
ChainB
Resolution2.353 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B H30 M33 R39 G62 S63 I67 E84 A85 T111 V112 M153 S156 H6 M9 R15 G38 S39 I43 E60 A61 T87 V88 M129 S132 MOAD: Kd=45uM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008469 histone arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0035244 protein-arginine C-methyltransferase activity
GO:0042054 histone methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0018216 peptidyl-arginine methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lwp, PDBe:4lwp, PDBj:4lwp
PDBsum4lwp
PubMed24498306
UniProtQ57U70

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