Structure of PDB 4lue Chain B

Receptor sequence
>4lueB (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRTGFYISPRSTFSTLQELVDHYKKGNDGL
CQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK
HTKVAVKTMKPLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSL
LDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA
SLVCKIADFGLARVIPIKWTAPEAINFTIKSDVWSFGILLMEIVTYGRIP
YPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYI
QSVLDDFYTATESQYEEI
3D structure
PDB4lue Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
ChainB
Resolution3.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D290 R292 A294 N295 D308
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E524 Y527 E412 Y415
BS02 VSE B V281 A293 K295 V323 T338 M341 S345 D348 L393 D404 F405 V193 A205 K207 V227 T242 M245 S249 D252 L297 D308 F309 BindingDB: IC50=0.426580nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4lue, PDBe:4lue, PDBj:4lue
PDBsum4lue
PubMed24531473
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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