Structure of PDB 4lud Chain B

Receptor sequence
>4ludB (length=410) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETSYSL
SVRDYDPRQGDTVKHYKITLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP
WEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSVEA
FLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGS
KQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFG
LARVIPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNP
EVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDF
YTATESQYEE
3D structure
PDB4lud Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
ChainB
Resolution2.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D280 R282 A284 N285 D298
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CA B E524 Y527 E405 Y408
BS02 SK8 B L273 V281 A293 K295 I336 T338 M341 L393 D404 L169 V177 A189 K191 I230 T232 M235 L287 D298
BS03 CA B N391 D404 N285 D298
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4lud, PDBe:4lud, PDBj:4lud
PDBsum4lud
PubMed24531473
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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