Structure of PDB 4lh3 Chain B

Receptor sequence
>4lh3B (length=545) Species: 10090 (Mus musculus) [Search protein sequence]
SHMLRWKHTSSLKVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVV
GDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDL
KPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELID
FFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGN
LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPT
FGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGK
NFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRL
LEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAG
GQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLK
LVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQ
PFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ
3D structure
PDB4lh3 Structural basis of substrate selectivity of Delta (1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): Semialdehyde chain length.
ChainB
Resolution1.813 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N211 K233 E314 C348 E447 P532
Catalytic site (residue number reindexed from 1) N193 K215 E296 C330 E429 P514
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUA B F212 K347 C348 S349 G512 S513 F520 F194 K329 C330 S331 G494 S495 F502 MOAD: Ki=30mM
Gene Ontology
Molecular Function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006560 proline metabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4lh3, PDBe:4lh3, PDBj:4lh3
PDBsum4lh3
PubMed23928095
UniProtQ8CHT0|AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Gene Name=Aldh4a1)

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