Structure of PDB 4lgu Chain B

Receptor sequence
>4lguB (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
SSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFC
CDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY
3D structure
PDB4lgu Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C48 C51 H68 C75
BS02 1YH B D297 G306 L307 R308 C309 W310 E311 D314 W323 D45 G54 L55 R56 C57 W58 E59 D62 W71 MOAD: ic50=2.1nM
External links
PDB RCSB:4lgu, PDBe:4lgu, PDBj:4lgu
PDBsum4lgu
PubMed23928071
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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