Structure of PDB 4lgd Chain B

Receptor sequence
>4lgdB (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP
VESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSD
IIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGH
AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI
TSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCL
VKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQREL
EEEELSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQ
3D structure
PDB4lgd Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
ChainB
Resolution3.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N146 K148 G150 N151 D164 D173 T184
Catalytic site (residue number reindexed from 1) N137 K139 G141 N142 D155 D164 T175
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R467 Y470 R474 I477 L478 R329 Y332 R336 I339 L340
BS02 ANP B G36 S37 A54 K56 C102 D109 D164 G27 S28 A45 K47 C93 D100 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4lgd, PDBe:4lgd, PDBj:4lgd
PDBsum4lgd
PubMed23972470
UniProtQ13188|STK3_HUMAN Serine/threonine-protein kinase 3 (Gene Name=STK3)

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