Structure of PDB 4lg1 Chain B

Receptor sequence
>4lg1B (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
RSFVRVLEKRDGTVLRLQQYSSGGVGCVVWDAAIVLSKYLETPEFSGDGA
HALSRRSVLELGSGTGAVGLMAATLGADVVVTDLEELQDLLKMNINMNKH
LVTGSVQAKVLKWGEEIEPSPPDFILMADCIYYEESLEPLLKTLKDISGF
ETCIICCYEQRTMGKNPEIEKKYFELLQLDFDFEKIPLEKHDEEYRSEDI
HIIYIRKKKSKFP
3D structure
PDB4lg1 The Crystal Structure of Human Methyltransferase-Like Protein 21D in Complex with SAM
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B W43 A46 G75 G77 D96 L97 K125 W126 A143 Y147 Y148 W30 A33 G62 G64 D83 L84 K112 W113 A128 Y132 Y133
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0051117 ATPase binding
Biological Process
GO:0006338 chromatin remodeling
GO:0018022 peptidyl-lysine methylation
GO:0018023 peptidyl-lysine trimethylation
GO:0032259 methylation
GO:0032780 negative regulation of ATP-dependent activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lg1, PDBe:4lg1, PDBj:4lg1
PDBsum4lg1
PubMed
UniProtQ9H867|MT21D_HUMAN Protein N-lysine methyltransferase METTL21D (Gene Name=VCPKMT)

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