Structure of PDB 4lac Chain B

Receptor sequence
>4lacB (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
QNFIIPKKEIHTVPDMGKWKRSQAYADYIGFILTLNEGVKGKKLTFEYRV
SEAIEKLVALLNTLDRWIDETPPVDQPSRFGNKAYRTWYAKLDEEAENLV
ATVVPTHLAAAVPEVAVYLKESVGNSTRIDYGTGHEAAFAAFLCCLCKIG
VLRVDDQIAIVFKVFNRYLEVMRKLQKTYRMEPAGSQGVWGLDDFQFLPF
IWGSSQLIDHPYLEPRHFVDEKAVNENHKDYMFLECILFITEMKTGPFAE
HSNQLWNISAVPSWSKVNQGLIRMYKAECLEKFPVIQHFKFGSLLPIHPV
T
3D structure
PDB4lac Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone.
ChainB
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS B R148 G152 T153 G154 A204 G205 P304 V305 H308 R128 G132 T133 G134 A184 G185 P284 V285 H288
Gene Ontology
Molecular Function
GO:0019211 phosphatase activator activity

View graph for
Molecular Function
External links
PDB RCSB:4lac, PDBe:4lac, PDBj:4lac
PDBsum4lac
PubMed24100351
UniProtQ15257|PTPA_HUMAN Serine/threonine-protein phosphatase 2A activator (Gene Name=PTPA)

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