Structure of PDB 4l9z Chain B

Receptor sequence
>4l9zB (length=314) Species: 272943 (Cereibacter sphaeroides 2.4.1) [Search protein sequence]
SFRLQPAPPARPNRCQLFGPGSRPALFEKMAASAADVINLDLEDSVAPDD
KAQARANIIEAINGLDWGRKYLSVRINGLDTPFWYRDVVDLLEQAGDRLD
QIMIPKVGCAADVYAVDALVTAIERAKGRTKPLSFEVIIESAAGIAHVEE
IAASSPRLQAMSLGAADFAASMGMQTTGIGGTQENYYMLHDGQKHWSDPW
HWAQAAIVAACRTHGILPVDGPFGDFSDDEGFRAQARRSATLGMVGKWAI
HPKQVALANEVFTPSETAVTEAREILAAMDAAKARGEGATVYKGRLVDIA
SIKQAEVIVRQAEM
3D structure
PDB4l9z The crystal structures of the tri-functional Chloroflexus aurantiacus and bi-functional Rhodobacter sphaeroides malyl-CoA lyases and comparison with CitE-like superfamily enzymes and malate synthases.
ChainB
Resolution2.011 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.3.24: malyl-CoA lyase.
4.1.3.25: (S)-citramalyl-CoA lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B F19 G20 R24 L27 K30 M31 S46 R76 I251 H252 P253 F18 G19 R23 L26 K29 M30 S45 R75 I250 H251 P252
BS02 OXL B R76 E141 G165 A167 D168 P223 W249 R75 E140 G164 A166 D167 P222 W248
BS03 MG B E141 D168 E140 D167
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0043959 L-erythro-3-methylmalyl-CoA lyase activity
GO:0046872 metal ion binding
GO:0047777 (S)-citramalyl-CoA lyase activity
GO:0050083 malyl-CoA lyase activity
Biological Process
GO:0006107 oxaloacetate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4l9z, PDBe:4l9z, PDBj:4l9z
PDBsum4l9z
PubMed24206647
UniProtQ3J5L6|MCAL_CERS4 L-malyl-CoA/beta-methylmalyl-CoA lyase (Gene Name=mcl1)

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