Structure of PDB 4l3t Chain B

Receptor sequence

>4l3tB (length=978) Species: 9606 (Homo sapiens)

AAACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLA
REDTNNLFSVQFRTTPMDSTGVPHILQHTVLCGSQKYPCRDPFFKMLNRS
LSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQE
GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHT
YSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQI
HEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDKQTTVSVSFLLPDI
TDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYNGYTREA
YFSVGLQGIVEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHKIEIQMK
HQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQE
KVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQI
YEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQY
CAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQ
QIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEI
FNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQ
ETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQ
QMPQTEKAVEDFLRSIGRSPVRHTVEKPVIRKLVMEPTFKPWQMKTHFLM
PFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGG
AKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSV
FSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYL
GTGKSTHGLAILGPENPKIAKDPSWIIR

3D structure

• PDB: 4l3t Molecular basis of substrate recognition and degradation by human presequence protease.
• Chain: B
• Resolution: 2.03 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H104 H108 E205	H74 H78 E175

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008047 enzyme activator activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006626 protein targeting to mitochondrion
• GO:0016485 protein processing

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:4l3t, PDBe:4l3t, PDBj:4l3t
• PDBsum: 4l3t
• PubMed: 24931469
• UniProt: Q5JRX3|PREP_HUMAN Presequence protease, mitochondrial (Gene Name=PITRM1)