Structure of PDB 4l0y Chain B

Receptor sequence
>4l0yB (length=104) Species: 9606 (Homo sapiens) [Search protein sequence]
PIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPK
MNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAML
DVKP
3D structure
PDB4l0y Structural basis of Ets1 activation by Runx1.
ChainB
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Q336 L337 W375 K379 K383 M384 K388 R391 Y395 Y396 Q3 L4 W42 K46 K50 M51 K55 R58 Y62 Y63 PDBbind-CN: Kd=3.1nM
BS02 dna B Y386 R391 R394 Y397 K404 R409 Y410 Y53 R58 R61 Y64 K71 R76 Y77 PDBbind-CN: Kd=3.1nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4l0y, PDBe:4l0y, PDBj:4l0y
PDBsum4l0y
PubMed24646888
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

[Back to BioLiP]