Structure of PDB 4kxn Chain B

Receptor sequence
>4kxnB (length=126) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTGDQFIHEQNLNWLQQA
DVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADG
SRFQVWDYAEGEVETMLDRYFEAYLV
3D structure
PDB4kxn N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6K6 B C15 G16 I18 R19 I65 N69 S87 G89 E93 C6 G7 I9 R10 I39 N43 S61 G63 E67 MOAD: Kd=0.8uM
PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
Gene Ontology
Molecular Function
GO:0070694 deoxyribonucleoside 5'-monophosphate N-glycosidase activity
Biological Process
GO:0009159 deoxyribonucleoside monophosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4kxn, PDBe:4kxn, PDBj:4kxn
PDBsum4kxn
PubMed24260472
UniProtO35820|DNPH1_RAT 5-hydroxymethyl-dUMP N-hydrolase (Gene Name=Dnph1)

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