Structure of PDB 4kto Chain B

Receptor sequence
>4ktoB (length=375) Species: 266834 (Sinorhizobium meliloti 1021) [Search protein sequence]
MMFEAGLNFALGEEIDALRASVRRFASERIAPLADDADRSNAFPMSLWRE
MGELGLLGITADEAHGGAGLGYLAHCVAMEEISRASASVGLSYGAHSNLC
VNQINRNGKPAQKSRYLPKLISGEHVGALAMSEPGVSMKLKADKRGDRYV
LNGSKMWITNGPDADVLVVYAKTDPARGITAFLVEKAFPGFSAGQKLDKL
GMRGSNTSELIFTDCEVPEENVLGGVGEGVKVLMSGLDYERVVLSAGPLG
IMAACLDVVVPYLHERKQGEFQLMQGKLADMYVTMNAARAYVYAVAAACD
RGETARKDAAGCILYAAEKATAMALEAIQALGGNGYTNDYPAGRLLRDAK
LYEIGAGTSEIRRMLIGRELFAETK
3D structure
PDB4kto Crystal structure of a Putative Isovaleryl-CoA dehydrogenase from Sinorhizobium meliloti 1021
ChainB
Resolution2.137 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) M130 S131 E247 A368 R380
Catalytic site (residue number reindexed from 1) M131 S132 E240 A356 R368
Enzyme Commision number 1.3.8.4: isovaleryl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B L128 M130 S131 W161 T163 L363 T370 E372 L129 M131 S132 W157 T159 L351 T358 E360
BS02 FAD B R273 Q275 E282 F283 M286 Q341 A342 G345 R266 Q268 E270 F271 M274 Q329 A330 G333
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003995 acyl-CoA dehydrogenase activity
GO:0008470 3-methylbutanoyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006552 L-leucine catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4kto, PDBe:4kto, PDBj:4kto
PDBsum4kto
PubMed
UniProtQ92VK1

[Back to BioLiP]