Structure of PDB 4kqx Chain B

Receptor sequence
>4kqxB (length=335) Species: 649764 (Slackia exigua ATCC 700122) [Search protein sequence]
MAVTILYEQDVDPKVIQGLKVGIIGYGSQGHAHALNLMDSGVDVRVGLRE
GDSDWKTAEEAGLKVTDMDTAAEEADVIMVLVPDEVQPKVYQEHIAAHLK
AGNTLAFAHGFNIHYGYIVPPEDVNVIMCAPKGPGHIVRRQFTEGSGVPD
LACVQQDATGNAWDIVLSYCWGVGGARSGIIKATFAEETEEDLFGEQAVL
CGGLVELVKAGFETLTEAGYPPELAYFECYHEMKMIVDLMYESGIHFMNY
SISNTAEYGEYYAGPKVINEQSREAMKEILKRIQDGSFAQEFVDDCNNGH
KRLLEQREAINTHPIETTGAQIRSMFSWIKKEDLE
3D structure
PDB4kqx General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K141 D201 E205
Catalytic site (residue number reindexed from 1) K132 D192 E196
Enzyme Commision number 1.1.1.86: ketol-acid reductoisomerase (NADP(+)).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004455 ketol-acid reductoisomerase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050661 NADP binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4kqx, PDBe:4kqx, PDBj:4kqx
PDBsum4kqx
PubMed23776225
UniProtD0WGK0|ILVC_SLAES Ketol-acid reductoisomerase (NADP(+)) (Gene Name=ilvC)

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