Structure of PDB 4kh6 Chain B

Receptor sequence
>4kh6B (length=596) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
VDADTEKRINVGKTHLQTLRNLETRCHDSLQALVVIDAGSSSTRTNVFLA
KTRSCPNKGRSIDPDSIQLIREGKRFTGLRVVLEEWLDTYAGKDWESRPV
DARLLFQYVPQMHEGAKKLMQLLEEDTVAILDSQLNEEQKVQVKALGIPV
MLCSTAGVRDFHEWYRDALFVLLRHLINNPSPAHGYKFFTNPFWTRPITG
AEEGLFAFITLNHLSRRLGEDPARSMIDEYGVKHSRNDLAGVVEVGGASA
QIVFPLQEGTVLPSSVRAVNLQRERLLPERYPSADVVSVSFMQLGMASSA
GLFLKELCSNDEFLQGGICSNPCLFKGFQQSCSAGEVEVRPDGSASVNED
VRKNRLKPLATYCSVHNPEISFKVTNEMQCRENSIDPTKPLAERMKIENC
SIIEGTGNFDKCVSQVESILVAPKLPLPANIEAASSGFESVDQVFRFASS
TAPMFITGRGMLASIDTLKDHRLLRSDFSGDVEELAEAAREFCSSEVIIR
TDGPVIQLPNARGEQKLNSLNFDLCKTMALTVSLLRHMAAGENQPSFIKW
EKSIAGPDGKPLADLGWQVGVILHHVLFTEEWGRTAYEAGYSHNLE
3D structure
PDB4kh6 The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AU1 B G72 S73 S74 R77 T188 A189 G280 A281 G39 S40 S41 R44 T155 A156 G247 A248
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
Cellular Component
GO:0005576 extracellular region
GO:0020003 symbiont-containing vacuole

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Molecular Function
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Cellular Component
External links
PDB RCSB:4kh6, PDBe:4kh6, PDBj:4kh6
PDBsum4kh6
PubMed24115522
UniProtQ27895|NTP2_TOXGO Nucleoside-triphosphatase 2 (Gene Name=NTP1)

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