Structure of PDB 4kgl Chain B

Receptor sequence
>4kglB (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]
APHLVQVDAARALWPLRRFWRSTGFCPPLPHSQADPYVLSWDQQLNLAYV
GAVPHRGIKQVRTHWLLELVTTRGSTLSYNFTHLDGYLDLLRENQLLPGF
ELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETW
NEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPR
SPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVA
QQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQ
NLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQ
LLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGP
ADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGL
CSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPAL
RLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWT
YEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPG
PFSDPVPYLEVP
3D structure
PDB4kgl Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.
ChainB
Resolution2.701 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.76: L-iduronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B L56 H58 L29 H31
BS02 MAN B C53 W306 S307 F352 C26 W276 S277 F322
BS03 IDJ B H91 N181 E182 K264 E299 V304 G305 W306 F352 R363 H64 N151 E152 K234 E269 V274 G275 W276 F322 R333
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4kgl, PDBe:4kgl, PDBj:4kgl
PDBsum4kgl
PubMed24036510
UniProtP35475|IDUA_HUMAN Alpha-L-iduronidase (Gene Name=IDUA)

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