Structure of PDB 4kgj Chain B

Receptor sequence
>4kgjB (length=607) Species: 9606 (Homo sapiens) [Search protein sequence]
APHLVQVDAARALWPLRRFWRSTGFCPPLDPYVLSWDQQLNLAYVGAVPH
RGIKQVRTHWLLELVTTRGSTLSYNFTHLDGYLDLLRENQLLPGFELMGS
ASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDH
HDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSW
GLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQ
LFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLA
NTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKP
VLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWR
AAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDG
EWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSL
LLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQF
SQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDP
VPYLEVP
3D structure
PDB4kgj Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.
ChainB
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.76: L-iduronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B C53 W306 S307 C26 W271 S272
BS02 IDF B H91 N181 E182 K264 E299 V304 G305 W306 D349 F352 R363 H59 N146 E147 K229 E264 V269 G270 W271 D314 F317 R328
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4kgj, PDBe:4kgj, PDBj:4kgj
PDBsum4kgj
PubMed24036510
UniProtP35475|IDUA_HUMAN Alpha-L-iduronidase (Gene Name=IDUA)

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