Structure of PDB 4keh Chain B

Receptor sequence
>4kehB (length=165) Species: 562 (Escherichia coli) [Search protein sequence]
KRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKG
YVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGK
GRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGR
LIYTASDLKVGLFQD
3D structure
PDB4keh Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
ChainB
Resolution1.901 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H70 V76 G79 C80 D84
Catalytic site (residue number reindexed from 1) H68 V74 G77 C78 D82
Enzyme Commision number 4.2.1.59: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase.
5.3.3.14: trans-2-decenoyl-[acyl-carrier-protein] isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1R3 B Q27 G91 R104 A105 Q25 G89 R102 A103
BS02 1R3 B H70 F71 G79 F113 T114 G115 Q116 Y155 H68 F69 G77 F111 T112 G113 Q114 Y153
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
GO:0034017 trans-2-decenoyl-acyl-carrier-protein isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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External links
PDB RCSB:4keh, PDBe:4keh, PDBj:4keh
PDBsum4keh
PubMed24362570
UniProtP0A6Q3|FABA_ECOLI 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (Gene Name=fabA)

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