Structure of PDB 4ke5 Chain B

Receptor sequence
>4ke5B (length=547) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYATTSRSAGQRQK
KVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSAKSK
YGYGAKDVRNLSSRAVNHIHSVWKDLLEDTVTPIDTTIMAKNEVFCVQPG
RKPARLIVFPDLGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEF
LVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAI
KSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAAC
RAAKLQDCTMLVYGDDLVVICESAGTQEDAASLRVFTEAMTRYSAPPGDP
PQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHT
PVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYS
IEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHR
ARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTPIPAGYSGGDIYH
3D structure
PDB4ke5 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PV B P197 R200 L204 L314 Y316 I363 S365 C366 S368 M414 Y415 Y448 P194 R197 L201 L311 Y313 I360 S362 C363 S365 M411 Y412 Y445
BS02 1PV B S476 Y477 L497 R498 R501 W528 V530 K531 S473 Y474 L494 R495 R498 W525 V527 K528
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4ke5, PDBe:4ke5, PDBj:4ke5
PDBsum4ke5
PubMed23672667
UniProtP26663|POLG_HCVBK Genome polyprotein

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