Structure of PDB 4kbb Chain B

Receptor sequence

>4kbbB (length=417) Species: 1491 (Clostridium botulinum) [Search protein sequence]

NNIILNLRYKDNNLIDLSGYGAKVEVYDGVELNDKNQFKLTSSANSKIRV
TQNQNIIFNSVFLDFSVSFWIRIPKYKNDGIQNYIHNEYTIINCMKNNSG
WKISIRGNRIIWTLIDINGKTKSVFFEYNIREDISEYINRWFFVTITNNL
NNAKIYINGKLESNTDIKDIREVIANGEIIFKLDGDIDRTQFIWMKYFSI
FNTELSQSNIEERYKIQSYSEYLKDFWGNPLMYNKEYYMFNAGNKNSYIK
LKKDSPVGEILTRSKYNQNSKYINYRDLYIGEKFIIRRKDIVRKEDYIYL
DFFNLNQEWRVYTYKYFKKEEEKLFLAPISDSDEFYNTIQIKEYDEQPTY
SCQLLFKKDEESTDEIGLIGIHRFYESEYKDYFCISKWYLKEVKRKPYNL
KLGCNWQFIPKDEGWTE

3D structure

PDB

4kbb Structure of dual receptor binding to botulinum neurotoxin B.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Q898 R967
Catalytic site (residue number reindexed from 1)	Q37 R106
Enzyme Commision number	3.4.24.69: bontoxilysin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	D1115 S1116 P1117 V1118 Y1181 Y1183 E1191 K1192 F1194 P1197 S1199 E1203 F1204	D254 S255 P256 V257 Y312 Y314 E322 K323 F325 P328 S330 E334 F335
BS02	BGC	B	F986 T1026	F125 T165
BS03	GAL	B	S1024 N1025	S163 N164
BS04	GAL	B	E1190 I1240 H1241 S1260 W1262 Y1263	E321 I371 H372 S386 W388 Y389
BS05	SIA	B	G1104 N1105 Y1263 N1273 K1275 L1276 G1277	G243 N244 Y389 N399 K401 L402 G403

Gene Ontology

	Cellular Component
GO:0005576	extracellular region

View graph for
Cellular Component

External links

PDB	RCSB:4kbb, PDBe:4kbb, PDBj:4kbb
PDBsum	4kbb
PubMed	23807078
UniProt	P10844\|BXB_CLOBO Botulinum neurotoxin type B (Gene Name=botB)

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