Structure of PDB 4kat Chain B

Receptor sequence
>4katB (length=220) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMGLKDEERDRHLIEYLM
KHGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSKLSYEFY
IPSPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIV
LPLNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCP
WTFEAFLKYAYKGDILKEVQ
3D structure
PDB4kat Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design.
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DU B E86 S88 G89 R90 R147 E87 S89 G90 R91 R148
BS02 FDA B R78 H79 R80 I81 N169 L173 H178 A179 R79 H80 R81 I82 N170 L174 H179 A180
BS03 FDA B N85 E86 Y91 N86 E87 Y92
BS04 DU B Q75 R78 Q76 R79
BS05 FDA B S30 T55 E58 I81 N163 R165 S31 T56 E59 I82 N164 R166
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4kat, PDBe:4kat, PDBj:4kat
PDBsum4kat
PubMed24563811
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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