Structure of PDB 4k96 Chain B

Receptor sequence
>4k96B (length=358) Species: 10090 (Mus musculus) [Search protein sequence]
SPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKPRGNP
LSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLL
IRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYL
VPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKEC
LKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSS
CFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYER
NNGFPIFD
3D structure
PDB4k96 Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
ChainB
Resolution2.084 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T334 K335 T338 R342 T187 K188 T191 R195
BS02 dna B K315 R342 K168 R195
BS03 dna B R158 L159 K160 R161 R180 E386 K395 R13 L14 K15 R16 R35 E239 K248
BS04 dna B S165 A168 N196 Y200 Y201 K372 S20 A23 N51 Y55 Y56 K225
External links
PDB RCSB:4k96, PDBe:4k96, PDBj:4k96
PDBsum4k96
PubMed23647843
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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