Structure of PDB 4k5y Chain B

Receptor sequence
>4k5yB (length=396) Species: 9606,10665 [Search protein sequence]
HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFIL
RNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLH
TAIVLTNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLSVAKSE
LDKAIGRNSNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVR
RSALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNR
AKRVIATFRTGTWDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEK
CWAGKRYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQAR
KAVKATLVLLPLLGITYMLAVFIYFNAFLESFQGFFVSVFACFLNS
3D structure
PDB4k5y Structure of class B GPCR corticotropin-releasing factor receptor 1.
ChainB
Resolution2.977 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E116 D125
Enzyme Commision number ?
3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1Q5 B F203 M206 L280 N283 T316 L320 Y327 F89 M92 L320 N323 T356 L360 Y367
BS02 PGW B L135 F138 N157 I232 W236 L21 F24 N43 I275 W279
BS03 PGW B C128 I129 V132 A133 V136 L140 C14 I15 V18 A19 V22 L26
BS04 PGW B H199 Y270 Q273 M276 A277 L280 F284 Y327 H85 Y310 Q313 M316 A317 L320 F324 Y367
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4k5y, PDBe:4k5y, PDBj:4k5y
PDBsum4k5y
PubMed23863939
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P34998|CRFR1_HUMAN Corticotropin-releasing factor receptor 1 (Gene Name=CRHR1)

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