Structure of PDB 4k1c Chain B

Receptor sequence
>4k1cB (length=371) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAI
IPLAAILANATEELADKAGNTIGGLLNATFGNAVELIVSIIALKKGQVRI
VQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTFNQTAAQTMSSLLAIACA
SLLIPAAFRATLPDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQ
EEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVV
ESTGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQV
ALFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNWL
EGVMSLAMYILIAMAFFYYPD
3D structure
PDB4k1c Structural basis for alternating access of a eukaryotic calcium/proton exchanger.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D373 E375 D344 E346
BS02 CA B E302 S325 E273 S296
BS03 CA B E83 E230 D234 E62 E201 D205
BS04 CA B E83 E230 D234 E62 E201 D205
BS05 MN B D373 E375 S376 E380 D344 E346 S347 E351
Gene Ontology
Molecular Function
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015369 calcium:proton antiporter activity
GO:0015386 potassium:proton antiporter activity
GO:0046872 metal ion binding
Biological Process
GO:0006812 monoatomic cation transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000324 fungal-type vacuole
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4k1c, PDBe:4k1c, PDBj:4k1c
PDBsum4k1c
PubMed23685453
UniProtQ99385|VCX1_YEAST Vacuolar calcium ion transporter (Gene Name=VCX1)

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