Structure of PDB 4jvs Chain B

Receptor sequence
>4jvsB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
EYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD
GKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESFNNVKQWL
QEIDRYASENVNKLLVGNKCDLTTKKVVDYTTAKEFADSLGIPFLETSAK
NATNVEQSFMTMAAEIKKRM
3D structure
PDB4jvs Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP
ChainB
Resolution2.783 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q70
Catalytic site (residue number reindexed from 1) Q64
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP B G21 G23 K24 S25 C26 Y36 E38 Y40 K125 D127 L128 S154 A155 K156 G15 G17 K18 S19 C20 Y30 E32 Y34 K119 D121 L122 S148 A149 K150
BS02 AF3 B S20 K24 S42 T43 Q70 S14 K18 S36 T37 Q64
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4jvs, PDBe:4jvs, PDBj:4jvs
PDBsum4jvs
PubMed23588383
UniProtP62820|RAB1A_HUMAN Ras-related protein Rab-1A (Gene Name=RAB1A)

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