Structure of PDB 4jvg Chain B

Receptor sequence
>4jvgB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK
FEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGL
ATSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAE
IEELARELS
3D structure
PDB4jvg Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
ChainB
Resolution3.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D129 K131 N133 N134 D147 S153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B96 B K483 E501 V504 L514 I527 T529 W531 C532 H574 G593 D594 K36 E54 V57 L67 I80 T82 W84 C85 H127 G146 D147 BindingDB: Kd=2700nM,IC50=83.4nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4jvg, PDBe:4jvg, PDBj:4jvg
PDBsum4jvg
PubMed23685672
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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