Structure of PDB 4jvb Chain B

Receptor sequence
>4jvbB (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPK
KILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNS
TNTWQSLIEAAQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
3D structure
PDB4jvb Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1M0 B M20 L22 W32 V49 I53 R61 Q78 V80 I109 A111 M117 I129 L147 Y149 M19 L21 W31 V48 I52 R60 Q77 V79 I108 A110 M113 I125 L143 Y145 MOAD: Kd=39nM
PDBbind-CN: -logKd/Ki=7.41,Kd=39nM
BindingDB: Kd=39nM
Gene Ontology
Molecular Function
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0007601 visual perception
GO:0050953 sensory perception of light stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jvb, PDBe:4jvb, PDBj:4jvb
PDBsum4jvb
PubMed23698361
UniProtO43924|PDE6D_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Gene Name=PDE6D)

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