Structure of PDB 4jsc Chain B

Receptor sequence
>4jscB (length=83) Species: 8355 (Xenopus laevis) [Search protein sequence]
KLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHIV
HCSNDPLGELFGVQEFSVKEHRRIYAMISRNLV
3D structure
PDB4jsc Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1OY B L50 M58 V89 K90 H92 I95 Y96 L29 M37 V68 K69 H71 I74 Y75 MOAD: ic50=74nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4jsc, PDBe:4jsc, PDBj:4jsc
PDBsum4jsc
PubMed23808545
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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