Structure of PDB 4jrq Chain B

Receptor sequence
>4jrqB (length=459) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QSTFLFHDYETFGTHPALDRPAQFAAIRTDSEFNVIGEPEVFYCKPADDY
LPQPGAVLITGITPQEARAKGENEAAFAARIHSLFTVPKTCILGYNNVRF
DDEVTRNIFYRNFYDPYAWSWQHDNSRWDLLDVMRACYALRPEGINWPEN
DDGLPSFRLEHLTKANGIEDAMADVYATIAMAKLVKTRQPRLFDYLFTHR
NKHKLMALIDVPQMKPLVHVSGMFGAWRGNTSWVAPLAWHPENRNAVIMV
DLAGDISPLLELDSDTLRERLYTAKTDLGDNAAVPVKLVHINKCPVLAQA
NTLRPEDADRLGINRQHCLDNLKILRENPQVREKVVAIFAEAPSDNVDAQ
LYNGFFSDADRAAMKIVLETEPRNLPALDITFVDKRIEKLLFNYRARNFP
GTLDYAEQQRWLEHRRQVFTPEFLQGYADELQMLVQQYADDKEKVALLKA
LWQYAEEIV
3D structure
PDB4jrq Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B D15 Y16 E17 T18 T21 I66 T67 Y102 N103 F107 R113 Y124 W128 R142 F164 G234 M235 A238 Y284 T285 A286 K287 N304 Y368 F371 D8 Y9 E10 T11 T14 I59 T60 Y95 N96 F100 R106 Y117 W121 R135 F157 G222 M223 A226 Y272 T273 A274 K275 N292 Y352 F355
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
GO:0046872 metal ion binding
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006274 DNA replication termination
GO:0006281 DNA repair
GO:0006308 DNA catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4jrq, PDBe:4jrq, PDBj:4jrq
PDBsum4jrq
PubMed23609540
UniProtP04995|EX1_ECOLI Exodeoxyribonuclease I (Gene Name=sbcB)

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