Structure of PDB 4jr0 Chain B

Receptor sequence
>4jr0B (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
NADNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNL
KYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTN
GPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTIPVEADFLYAYSTAP
GYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFS
FDATFHAKKQIPCIVSMLTKELYFYH
3D structure
PDB4jr0 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation.
ChainB
Resolution1.796 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) T31 S32 H90 G91 C132 R133
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R64 S120 Q161 C163 S205 W206 R207 N208 S249 F250 R33 S89 Q130 C132 S154 W155 R156 N157 S198 F199
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4jr0, PDBe:4jr0, PDBj:4jr0
PDBsum4jr0
PubMed23650375
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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