Structure of PDB 4jlg Chain B

Receptor sequence
>4jlgB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
VCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEG
KLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVY
VAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTL
SLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIK
CIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQAT
3D structure
PDB4jlg (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
ChainB
Resolution1.896 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y245 H293 H297 Y305 Y335
Catalytic site (residue number reindexed from 1) Y128 H176 H180 Y188 Y218
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B A226 E228 N265 H293 K294 N296 H297 Y335 W352 E356 A109 E111 N148 H176 K177 N179 H180 Y218 W235 E239
BS02 1L8 B H252 D256 W260 T266 L267 S268 Y305 Y335 G336 Y337 H339 S340 H135 D139 W143 T149 L150 S151 Y188 Y218 G219 Y220 H222 S223 BindingDB: IC50=2.0nM,Ki=0.330000nM
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0140945 histone H3K4 monomethyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jlg, PDBe:4jlg, PDBj:4jlg
PDBsum4jlg
PubMed25136132
UniProtQ8WTS6|SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (Gene Name=SETD7)

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