Structure of PDB 4jk9 Chain B

Receptor sequence
>4jk9B (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
ELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFL
KIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGML
DPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNL
YDDWLKTISSYTAFSRLILILRALHVNNDRAKVILKPDKTTITEPHHIWP
TLTDEEWIKVEVQLKDLILA
3D structure
PDB4jk9 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO B D1922 H1965 H1966 D153 H196 H197
Gene Ontology
Biological Process
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0005681 spliceosomal complex

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Biological Process
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Cellular Component
External links
PDB RCSB:4jk9, PDBe:4jk9, PDBj:4jk9
PDBsum4jk9
PubMed23686287
UniProtQ6P2Q9|PRP8_HUMAN Pre-mRNA-processing-splicing factor 8 (Gene Name=PRPF8)

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