Structure of PDB 4jjf Chain B

Receptor sequence
>4jjfB (length=344) Species: 79929 (Methanothermobacter marburgensis str. Marburg) [Search protein sequence]
MKLAILGAGCYRTHAASGITNFSRACEVAEMVGKPEIAMTHSTITMGAEL
KELAGVDEVVVADPVFDNQFTVIDDFAYEDVIEAHKEDPEKIMPQIREKV
NEVAKELPKPPEGAIHFTHPEDLGFEITTDDREAVADADFIMTWFPKGDM
QPDIINKFIDDIKPGAIVTHACTIPTTKFYKIFEQKHGDLVTKPETLNVT
SYHPGAVPEMKGQVYIAEGYASEDAIETLFELGQKARGNAYRLPAELLGP
VCDMCSALTAITYAGILSYRDSVTQVLGAPASFAQMMAKESLEQITALME
KVGIDKMEENLDPGALLGTADSMNFGASAEILPTVFEILEKRKK
3D structure
PDB4jjf Crystal structures of [fe]-hydrogenase in complex with inhibitory isocyanides: implications for the h2 -activation site.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.12.98.2: 5,10-methenyltetrahydromethanopterin hydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE9 B L6 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 A171 C172 P204 A206 L6 G7 G9 A62 D63 P64 P110 P111 D131 W144 F145 P146 I154 A171 C172 P204 A206 PDBbind-CN: -logKd/Ki=8.00,Ki=10nM
BS02 N2I B C172 C252 C172 C252 MOAD: Ki=10nM
PDBbind-CN: -logKd/Ki=8.00,Ki=10nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047068 N5,N10-methenyltetrahydromethanopterin hydrogenase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015948 methanogenesis
GO:0019386 methanogenesis, from carbon dioxide

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4jjf, PDBe:4jjf, PDBj:4jjf
PDBsum4jjf
PubMed23873755
UniProtP32440|HMD_METTM 5,10-methenyltetrahydromethanopterin hydrogenase (Gene Name=hmd)

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