Structure of PDB 4je7 Chain B

Receptor sequence
>4je7B (length=189) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
LPEIVASGDPVLHEKAREVDPGEIGSERIQKIIDDMIKVMRLAPCVGLAA
PQIGVPLRIIVLEDTKEYISYAPKEEILAQERRHFDLMVMVNPVLKERSN
KKALFFEGCESVDGFRAAVERYLEVVVTGYDRQGKRIEVNASGWQARILQ
HECDHLDGNLYVDKMVPRTFRTVDNLDLPLAEGCPKLGS
3D structure
PDB4je7 Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G49 Q54 C111 E112 H153 E154 H157
Catalytic site (residue number reindexed from 1) G47 Q52 C109 E110 H151 E152 H155
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BB2 B P46 C47 V48 G49 Q54 R84 E109 G110 C111 E112 R118 W146 R149 H153 E154 H157 P44 C45 V46 G47 Q52 R82 E107 G108 C109 E110 R116 W144 R147 H151 E152 H155 MOAD: Kd=395nM
BindingDB: IC50=27nM
BS02 ZN B C111 H153 H157 C109 H151 H155
Gene Ontology
Molecular Function
GO:0042586 peptide deformylase activity

View graph for
Molecular Function
External links
PDB RCSB:4je7, PDBe:4je7, PDBj:4je7
PDBsum4je7
PubMed24531459
UniProtQ9FV53|DEF1A_ARATH Peptide deformylase 1A, chloroplastic/mitochondrial (Gene Name=PDF1A)

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