Structure of PDB 4je5 Chain B

Receptor sequence
>4je5B (length=497) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TLPESKDFSYLFSDETNARKPSPLKTCIHLFQDPNIIFLGGGLPLKDYFP
WDNLSVDSPKPPFPQGIGAPIDEQNCIKYTVNKDYADKSANPSNDIPLSR
ALQYGFSAGQPELLNFIRDHTKIIHDLKYKDWDVLATAGNTNAWESTLRV
FCNRGDVILVEAHSFSSSLASAEAQGVITFPVPIDADGIIPEKLAKVMEN
WTPGAPKPKLLYTIPTGQNPTGTSIADHRKEAIYKIAQKYDFLIVEDEPY
YFLQMNPYIKDLKEREKAQSSPKQDHDEFLKSLANTFLSLDTEGRVIRMD
SFSKVLAPGTRLGWITGSSKILKPYLSLHEMTIQAPAGFTQVLVNATLSR
WGQKGYLDWLLGLRHEYTLKRDCAIDALYKYLPQSDAFVINPPIAGMFFT
VNIDASVHPEFKTKYNSDPYQLEQSLYHKVVERGVLVVPGSWFKSEGETE
PPQPAESKEVSNPNIIFFRGTYAAVSPEKLTEGLKRLGDTLYEEFGI
3D structure
PDB4je5 Crystal structure of Saccharomyces cerevisiae Aro8, a putative alpha-aminoadipate aminotransferase.
ChainB
Resolution1.909 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
2.6.1.57: aromatic-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EPE B F166 R470 F165 R469
BS02 PMP B G140 N141 T142 F166 I215 D248 P250 Y251 S302 S304 R312 G139 N140 T141 F165 I214 D247 P249 Y250 S301 S303 R311
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0008793 aromatic-amino-acid transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
GO:0080130 L-phenylalanine-2-oxoglutarate transaminase activity
Biological Process
GO:0006571 tyrosine biosynthetic process
GO:0009058 biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009074 aromatic amino acid family catabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019509 L-methionine salvage from methylthioadenosine
GO:0019878 lysine biosynthetic process via aminoadipic acid
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4je5, PDBe:4je5, PDBj:4je5
PDBsum4je5
PubMed23893908
UniProtP53090|ARO8_YEAST Aromatic/aminoadipate aminotransferase 1 (Gene Name=ARO8)

[Back to BioLiP]