Structure of PDB 4jd2 Chain B

Receptor sequence
>4jd2B (length=377) Species: 9913 (Bos taurus) [Search protein sequence]
QGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIREIKDLMVGDEA
SELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTE
PPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGD
GVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFE
TVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEA
PEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYP
GLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVL
ADIMKDKDNFWMTRQEYQEKGVRVLEK
3D structure
PDB4jd2 Structural basis for regulation of Arp2/3 complex by GMF.
ChainB
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B G14 T15 G16 F17 K19 G160 D161 G186 R214 K217 E218 G306 M309 Y310 G11 T12 G13 F14 K16 G149 D150 G175 R203 K206 E207 G295 M298 Y299
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0051015 actin filament binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2001032 regulation of double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005938 cell cortex
GO:0035861 site of double-strand break
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jd2, PDBe:4jd2, PDBj:4jd2
PDBsum4jd2
PubMed23893131
UniProtA7MB62|ARP2_BOVIN Actin-related protein 2 (Gene Name=ACTR2)

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