Structure of PDB 4jbl Chain B

Receptor sequence
>4jblB (length=335) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
EQISISSPRKRIYHNILETIGGTPLVELHGVTEHPRIKKGTRILVKLEYF
NPMSSVKDRVGFNIVYQAIKDGRLKPGMEIIESTSGNTGIALCQAGAVFG
YRVNIAMPSTMSVERQMIMKAFGAELILTEGKKGMPGAIEEVNKMIKENP
GKYFVANQFGNPDNTAAHHYTANEIWEDTDGEVDIVVSAVGTSGTVIGVA
EKLKEKKKGIKIIAVEPEESAVLEGKAKGPHGIQGIGAGFIPDIYKKEFV
DEIIPIKTQDAWKMARAVVKYDGIMCGMSSGAAILAGLKEAEKPENEGKT
IVIIVPSCGERYLSTDLYKIKDEGTKIQILDSLLN
3D structure
PDB4jbl Molecular basis of ligand recognition by OASS from E. histolytica: insights from structural and molecular dynamics simulation studies
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K58 S280
Catalytic site (residue number reindexed from 1) K57 S279
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET B X58 T85 S86 N88 T89 M136 Q159 F160 G192 G236 I237 A239 X57 T84 S85 N87 T88 M135 Q158 F159 G191 G235 I236 A238 MOAD: Kd=0.54mM
PDBbind-CN: -logKd/Ki=3.27,Kd=0.54mM
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4jbl, PDBe:4jbl, PDBj:4jbl
PDBsum4jbl
PubMed23747298
UniProtO15570

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