Structure of PDB 4j75 Chain B

Receptor sequence
>4j75B (length=369) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GINYNKLIKEFGCSKITENHIKRIEKLTNSKAHHFIRRGIFFSHRDLDFL
LNYYEQHKCFYIYTGRGPSSLSMHLGHLIPFYFCKYLQEAFNVPLVIQLS
DDEKYLFNQNYSLEYINTLTNENVKDIISVGLNPELTFIFKNTEYAGYLY
PTVLSIHKKTTLNQSMNVFGFNHSDNIGKISYPSFQIAPCFSQCFPNFLG
KNIPCLVPQGIDQDPYFRLSRDIAVKMALHKPVVVHSVFMPGLQGVNSKM
SSDHNNSVIFLTDTPEQIKNKINKYAFSGGGTTIQEHREKGGNLDKDISY
QYLRYLLEDDNKLNEIGEKYLSGEIKKILIDVLTELVLKHQEKKKSLTDE
EISYFFDPNKPSLQKFKNM
3D structure
PDB4j75 Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.2: tryptophan--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYM B Y306 T307 G308 R309 G310 G319 H320 P323 Q341 E346 K347 Q429 G453 D455 Q456 F460 F482 M483 M493 Y63 T64 G65 R66 G67 G76 H77 P80 Q98 E103 K104 Q186 G210 D212 Q213 F217 F239 M240 M250
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4j75, PDBe:4j75, PDBj:4j75
PDBsum4j75
PubMed23665145
UniProtQ8IDW3

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