Structure of PDB 4j5x Chain B

Receptor sequence
>4j5xB (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
GVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQV
RKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFK
GIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECG
RLSYCLEDTAQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGV
LQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQ
HTQRLLRIQDIHPFATPLMQELFGISSLTERHKILHRLLQEGS
3D structure
PDB4j5x Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRL B L209 V211 M243 S247 Q285 F288 W299 Y306 M323 H327 H407 M425 L57 V59 M91 S95 Q133 F136 W147 Y154 M167 H171 H251 M269
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4j5x, PDBe:4j5x, PDBj:4j5x
PDBsum4j5x
PubMed23602807
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2);
Q15788

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