Structure of PDB 4j57 Chain B

Receptor sequence
>4j57B (length=483) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
HTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGT
CVNVGCVPKKLMHYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSH
IRSLNFSYMTGLRSSKVKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKY
ILIATGCRPHIPDDVEGAKELSITSDDIFSLKKDPGKTLVVGASYVALEC
SGFLNSLGYDVTVAVRSIVLRGFDQQCAVKVKLYMEEQGVMFKNGILPKK
LTKMDDKILVEFSDKTSELYDTVLYAIGRKGDIDGLNLESLNMNVNKSNN
KIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEI
MDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAV
HRSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFD
NCIGIHPTDAESFMNLFVTISSGLSYAAKGGCG
3D structure
PDB4j57 Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) I84 C88 C93 K96 F143 Y232 E236 H509 E514 G533 G534
Catalytic site (residue number reindexed from 1) I47 C51 C56 K59 F106 Y195 E199 H456 E461 G480 G481
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G50 P51 G52 D71 Y72 G86 T87 C88 G92 C93 K96 G159 L160 A161 T192 G193 Y232 V233 R316 G356 D357 E364 L365 A366 G13 P14 G15 D34 Y35 G49 T50 C51 G55 C56 K59 G122 L123 A124 T155 G156 Y195 V196 R279 G319 D320 E327 L328 A329
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0045454 cell redox homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:4j57, PDBe:4j57, PDBj:4j57
PDBsum4j57
PubMed23845423
UniProtP61076|TRXR_PLAF7 Thioredoxin reductase (Gene Name=TRXR)

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