Structure of PDB 4j4n Chain B

Receptor sequence
>4j4nB (length=122) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
FEKVELTADGGVIKTILKKGDEGEENIPKKGNEVTVHYVGKLESTGKVFD
SSFDRNVPFKFHLEQGEVIKGWDICVSSMRKNEKCLVRIESMYGYGDEGC
GESIPGNSVLLFEIELLSFREL
3D structure
PDB4j4n Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent.
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y44 F55 D56 I75 Y101 F118
Catalytic site (residue number reindexed from 1) Y38 F49 D50 I69 Y95 F112
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D44 B F55 D56 F65 V74 I75 W78 Y101 I110 F49 D50 F59 V68 I69 W72 Y95 I104
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:4j4n, PDBe:4j4n, PDBj:4j4n
PDBsum4j4n
PubMed23974147
UniProtQ8I4V8|FKB35_PLAF7 Peptidyl-prolyl cis-trans isomerase FKBP35 (Gene Name=FKBP35)

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