Structure of PDB 4j26 Chain B

Receptor sequence
>4j26B (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMI
SWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSM
ADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHAS
NKGMEHLLNMKCKNVVPVYDLLLEMLNAH
3D structure
PDB4j26 Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I310 K314 L324 V328 E332 D489 E493 M494 I50 K54 L64 V68 E72 D220 E224 M225
BS02 EST B L298 E305 M336 L339 F356 H475 L476 L38 E45 M76 L79 F96 H206 L207 BindingDB: IC50=1.1nM,Kd=0.5nM,EC50=2.1nM,Ki=0.015nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4j26, PDBe:4j26, PDBj:4j26
PDBsum4j26
PubMed23437920
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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