Structure of PDB 4ixh Chain B

Receptor sequence
>4ixhB (length=334) Species: 5807 (Cryptosporidium parvum) [Search protein sequence]
GTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMD
TVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNSGGLRVGAAIGV
NEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVV
TEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVAS
KFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGD
TVYKYYRGMGSVGAMKSMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGY
LGSASIEELWKKSSYVEITTSGLRESHVHDVEIV
3D structure
PDB4ixh Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase.
ChainB
Resolution2.105 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q21 B S22 V24 L25 P26 S354 Y358 S21 V23 L24 P25 S296 Y300 MOAD: ic50=6.1nM
BindingDB: IC50=8.0nM,Ki=13nM
BS02 IMP B S48 M50 G216 S217 I218 C219 D252 G254 G275 S276 Y299 G301 M302 G303 E329 S47 M49 G173 S174 I175 C176 D209 G211 G232 S233 Y256 G258 M259 G260 E271
BS03 Q21 B A165 S169 N171 M302 G303 E329 A122 S126 N128 M259 G260 E271 MOAD: ic50=6.1nM
BindingDB: IC50=8.0nM,Ki=13nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ixh, PDBe:4ixh, PDBj:4ixh
PDBsum4ixh
PubMed23668331
UniProtQ8T6T2|IMDH_CRYPV Inosine-5'-monophosphate dehydrogenase (Gene Name=56k.02)

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