Structure of PDB 4iwf Chain B

Receptor sequence
>4iwfB (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVY
TKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK
GMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iwf Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainB
Resolution1.932 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 L379 E380 D538 L539 E542 I49 K53 L63 V67 L70 E71 D218 L219 E222
BS02 15Q B M343 L349 E353 F404 M421 H524 L525 M34 L40 E44 F95 M112 H204 L205
External links
PDB RCSB:4iwf, PDBe:4iwf, PDBj:4iwf
PDBsum4iwf
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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