Structure of PDB 4iwc Chain B

Receptor sequence

>4iwcB (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKPLSDLLLEMLDAHRL

3D structure

PDB

4iwc Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha

Chain

Resolution

2.24 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 Q375 V376 E380 D538 L539 E542	I54 K58 L68 Q71 V72 E76 D229 L230 E233
BS02	1GV	B	M343 L346 E353 M421	M39 L42 E49 M117

External links

PDB	RCSB:4iwc, PDBe:4iwc, PDBj:4iwc
PDBsum	4iwc
PubMed	23524984
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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