Structure of PDB 4iw8 Chain B

Receptor sequence
>4iw8B (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iw8 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainB
Resolution2.0375 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 V376 E380 D538 L539 E542 M543 I55 K59 V73 E77 D223 L224 E227 M228
BS02 KN3 B M343 L346 T347 E353 L387 R394 F404 L428 G521 L525 M528 M40 L43 T44 E50 L84 R91 F101 L125 G206 L210 M213
External links
PDB RCSB:4iw8, PDBe:4iw8, PDBj:4iw8
PDBsum4iw8
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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