Structure of PDB 4iw6 Chain B

Receptor sequence
>4iw6B (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4iw6 Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 V376 L379 E380 D538 L539 E542 I54 K58 V72 L75 E76 D225 L226 E229
BS02 1GU B L346 A350 E353 L387 F404 I424 L428 G521 L525 L540 L42 A46 E49 L83 F100 I117 L121 G208 L212 L227
External links
PDB RCSB:4iw6, PDBe:4iw6, PDBj:4iw6
PDBsum4iw6
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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