Structure of PDB 4ivw Chain B

Receptor sequence
>4ivwB (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4ivw Ligand binding dynamics rewire cellular signaling via Estrogen Receptor-alpha
ChainB
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 Q375 V376 E380 L539 E542 I55 K59 L69 Q72 V73 E77 L229 E232
BS02 1GJ B L346 T347 A350 E353 L384 L387 F404 M421 I424 G521 L525 L536 L540 L43 T44 A47 E50 L81 L84 F101 M116 I119 G211 L215 L226 L230
External links
PDB RCSB:4ivw, PDBe:4ivw, PDBj:4ivw
PDBsum4ivw
PubMed23524984
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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